ª中国中国科学院院，RCOG荣誉院士，发展中国家科学院院士

 Ø 主要学术贡献：

                率领中国开展大规模多中心辅助生殖技术(ART）出生队列研究↙

杜立中，浙江大学医学院附属儿童医院,教授，博导，儿科研究所所长。1982年毕业于浙江医科大学获得学士学位，1990年获医学博士学位。自1984年起在新生儿重症监护领域从事临床及研究。自1985年起，先后在美国、法国进修。已发表论文200余篇, 其中被SCI收录论文50余篇；主持7项国家自然科学基金项目，主持科技部“十二五”支撑项目2项。现任Societies for Pediatric Research (SPR)（美国）会员，现任中华医学会儿科分会常委，新生儿学组组长，浙江省医学会儿科学分会主任委员。担任国内外10余种学术期刊副主编或编委，包括BMC Pediatrics(副主编),《中华儿科杂志》副主编；The Journal of Pediatrics 编委；《儿科学》8年制、5年制规划教材副主编，《新生儿学》5年制规划教材主编。获得浙江省有突出贡献中青年专家和医药卫生领军人才等称号，2014年获中国儿科医师奖；2014年获浙江省科技进步一等奖。

工作研究项目：

1.  亚硝酸乙酯对胎粪性肺损伤及肺动脉高压的干预研究.国家自然科学基金,编号: 30371498，2004.1-2006.12（主持）

2.  红细胞SNO-Hb/Hb[FeNO]平衡对胎粪性肺损伤和肺动脉高压的调控，国家自然科学基金,编号:2007-2009（主持）

3.  评估危重新生儿稳定项目对降低中国农村地区新生儿死亡率和并发症的研究，国家自然科学基金,编号:2008-2010（主持）

4.  宫内生长迟缓致成年期肺动脉高压的内皮细胞调控机制. 国家自然科学基金,编号: (81070512),2011.1-2014.12（主持）

5.  新生儿危重症呼吸衰竭的综合救治技术研究. 国家科技支撑计划课题（十二五）,编号:2012BAI04B004),2012.1.1-2015-12.31（主持）

6.  儿童非感染性疾病新药临床评价研究技术平台建设.卫生部重大专项 2013ZX09303003  2013.1-2015.12（主持）

7.  miR-143调节生命早期营养受限致成年期肺动脉高压机制研究. 国家自然科学基金,编号: 81471480,2013.1-2015.12（主持）

8.  生命早期营养与肺血管内皮细胞功能的表观调控机制研究.国家自然科学基金,编号: 81471480,2014.1-2018.12（主持）

9.  围产期营养因素对早产儿肺血管发育的调控机制及干预策略.国家自然科学基金(重点项目), 2017.1-2021.12,编号: 81630037（主持）

发表论文：

1.     Chen Zhimin, Mao Jianhua, Du Lizhong.  Association of cytokine responses with disease severity in infants with respiratory syncytial virus infection. Acta Paediatr. 2002; 91(9):914-22  (supervisor)

2.      *Du Lizhong, Shi Liping, Sun Meiyue.  Inhaled nitric oxide in preterm and term neonates with hypoxemic respiratory failure and persistent pulmonary hypertension.  Acta Pharmacol Sin. 2002; 23suppl:69-73 (corresponding author)

3.     Shang S, Fu J,Dong G, *Du L, Yu X. Establishment and analysis of specific DNA patterns in 16S-23S rRNA gene spacer regions for differentiating different bacteria.Chin Med J (Engl). 2003 Jan; 116(1):129-33.

4.     Tang LF, *Du LZ, Chen ZM, Zou CC. Extracellular matrix remodeling in children with airway foreign-body aspiration. Pediatr Pulmonol. 2004 Aug; 38(2):140-5. (corresponding author)

5.     Tang LF, Du L, Zou CC, Gu WZ. Levels of matrix metalloproteinase-9 and its inhibitor in guinea pig asthma model following ovalbumin challenge.Fetal Pediatr Pathol. 2005 Mar-April; 24(2):81-87(corresponding author)

6.    An Chen, *Lizhong Du, Yaping Xu, Liqing Chen and Yidong Wu. The Effect of Blue Light Exposure on the Expression of Circadian Genes: Bmal1 and Cryptochrome 1 in Peripheral Blood Mononuclear Cells of Jaundiced Neonates. Pediatr Res. 2005; 58:1180-84 (corresponding author)

7.    Shang S, Chen G, Wu yi, Du L. Rapid diagnosis of bacterial sepsis with PCR amplification and microarray hybridization in 16S rRNA gene.  Pediatr Res. 2005 Jul;58(1):143-8. Epub 2005; Jun 27.

8.  Lu Meiping, *Du Lizhong, Gu Weizhong. Nitric oxide inhalation inhibits inducible nitric oxide synthase but not nitrotyrosine formation and cell apoptosis in rat lungs with meconium-induced injury. Acta Pharmacol Sin. 2005 Sep; 26(9):1123-9 (corresponding author)

9.     Tang LF, *Du Lizhong, Chen ZM, Zou CC Levels of matrix metalloproteinase-9 and its inhibitor in bronchoalveolar lavage cells of asthmatic children.  Fetal Pediatr Pathol. 2006 Jan-Feb; 256(1):1-7.  (corresponding author)

10.  Ge Sun, *Du Lizhong. Cord blood bilirubin level in relation to bilirubin UDP-glucuronosyltransferase gene missense allele in Chinese neonates. Acta Pædiatrica 2007, 96,1622–1625 (corresponding author)

11.  Xiu min Wang, Li Liang and *Lizhong Du. The effects of intrauterine undernutrition on pancreas ghrelin and insulin expression in neonate rats. Journal of Endocrinology 2007; 194, 121-129  (corresponding author)

12.  Wu YD, Chen LH, Wu XJ, Shang SQ, Lou JT, *Du LZ, Zhao ZY. Gram stain-specific-probe-based real-time PCR for diagnosis and discrimination of bacterial neonatal sepsis. J Clin Microbiol. 2008 Aug;46(8):2613-9. Epub 2008 Jun 11

13.  Xiaolu Ma, *Lizhong Du. The clinical outcomes of late preterm infants: a multi-center survey of Zhejiang, China.  J Perinat Med.  2009; Jul 10 (corresponding author)

14.  Xiling Wu, *Lizhong Du, Xuefeng Xu,Increased Nitrosoglutathione Reductase Activity in Hypoxic Pulmonary Hypertension in Mice. Journal of Pharmacological Sciences 2010; April 22, (corresponding author)

15.  Xue-Feng Xua, Xiao-Lu Maa, Zheng Chen, Li-Ping Shi and Li Zhong Du.Clinicalcharacteristics of nosocomial infections in neonatal intensive care unit in eastern China. J Perinat Med. 2010,38(4) (corresponding author)

16.  XUE-FENG XU, WEI-ZHONG GU, XI-LING WU, RU-YI LI, & *LI-ZHONG DU. Fetal Pulmonary Vascular Remodeling in a Rat Model Induced by Hypoxia and Indomethacin. The Journal of Maternal-Fetal & Neonatal Medicine, 2011 Jan;24(1):172-82 (corresponding author)

17.  Xu, Xue-Feng; Ma, Xiao-Lu; Shen, Zheng; Wu, Xi-Ling; Cheng, Fen; *Du, Li-Zhong. Epigenetic regulation of the endothelial nitric oxide synthase gene in persistent pulmonary hypertension of the newborn rat. Journal of Hypertension,2010,November  28(11)2227–2235(corresponding author)

18.  He Y, Jiang GP, Zhao L, Qian JJ, Yang XZ, Li XY, Du LZ, Shu Q. Ultrasonographic characteristics of urolithiasis in children exposed to melamine-tainted powdered formula. World J Pediatr. 2009 May;5(2):118-21.

Epub 2009 Jul 9.

19.  Dan Xu & Shuxian Li & Zhimin Chen & *Lizhong Du. Detection of Mycoplasma pneumoniae in different respiratory specimens. Eur J Pediatr. Epub Nov 2010 (corresponding author)

20.  MA Xiao-lu, XU Xue-feng, CHEN Chao, YAN Chao-ying, LIU Ya-ming, LIU Ling, XIONG Hong, SUN Hui-qing, LAI Jian-pu, YI Bin, SHI Jing-yun, DU Li-zhong*. Epidemiology of respiratory distress and the illness severity in late preterm or term infants: a prospective multi-center study. Chin Med J 2010;123(20):2776-2780 (corresponding author)

21.  XU Xue-feng and DU Li-zhong. Epigenetics in neonatal diseases. Chin Med J 2010;123(20):2948-2954 (corresponding author)

22.  Xue-Feng Xu, Fen Cheng and Li-Zhong Du*. Epigenetic regulation of pulmonary arterial hypertension. Hypertension Research 2011.34, 981-986 (corresponding author)

23.  Xu Yan-ping Xu, Jia-jun Zhu, Fen Cheng, Ke-wen Jiang, Wei-zhong Gu, Zheng Shen, Yi-dong Wu, Li Liang, and Li-zhong Du*. Ghrelin ameliorates hypoxia-induced pulmonary hypertension via phospho-GSK3β/β-catenin signaling in neonatal rats. J Mol Endocrinol2011 47 33-43 (corresponding author)

24.  Xue-Feng Xu, Wei-Zhong Gu, Xi-Ling Wu, Ru-Yi Li, & Li-Zhong Du*. Fetal Pulmonary Vascular Remodeling in a Rat Model Induced by Hypoxia and Indomethacin. The Journal of Maternal-Fetal & Neonatal Medicine, 2011 Jan;24(1):172-82 (corresponding author)

25.  Zhu J, Xu Y, Zhang G, Wu M, *Du L. Total serum bilirubin level in umbilical cord blood and respiratory distress syndrome in very low birth weight infants.J Perinat Med. 2011 Nov 16;40(1):91-5. (corresponding author)

26.  Zhu J, Xu Y, Zhang G, Bao Y, Wu M, *Du L. Total serum bilirubin levels during the

first 2 days of life and subsequent neonatal morbidity in very low birth weight infants: a retrospective review. Eur J Pediatr. 2012 Apr;171(4)669-74 (corresponding author)

27.  Xu Y, Ke H, Liang L, Wang X, Pei J, *Du L. PEG-rhGH therapy for small for gestational age rats and effects on their metabolic parameters. Horm Res Paediatr. 2011;76(1):35-43 (corresponding author)

28.  Dan Xu & Shuxian Li & Zhimin Chen & *Lizhong Du. Detection of Mycoplasma pneumoniae in different respiratory specimens. Eur J Pediatr. 2011 Jul;170(7):851-8 (corresponding author)

29.  Wu, Xiling; *Du, Lizhong; Wang, Xiumin. Congenital Monoblastic Leukemia Presenting as Jaundice, Pleural Effusion, and Ascites: Case Report and Literature Review. Fetal and Pediatric Pathology,2011; 30(1):27-31(5) (corresponding author)

30.  Jiang L, Wu YD, Xu XF, *DU LZ. Polymorphism analysis of the ABCA3 gene: association with neonatal respiratory distress syndrome in preterm infants.

Chin Med J (Engl). 2012 May;125(9):1594-8(corresponding author)

31.  Xue-Feng Xu, Ying Lv, Wei-Zhong Gu, Li-Li Tang, Jia-Kai Wei, Li-Yan Zhang and Li-Zhong Du*. Epigenetics of hypoxic pulmonary arterial hypertension following intrauterine growth retardation rat: epigenetics in PAH following IUGR. Respiratory Research 2013,14:20 (doi:10.1186/1465-9921-14-20) (corresponding author)

32.  *Lizhong Du, Xiaolu MA. International Perspectives: Hyperbilirubinemia and

Kernicterus in Neonates in China. Neoreviews 2012; 13:e141-e144(corresponding author)

33.  Yu Y, *Du L, Yuan T, Zheng J, Chen A, Chen L, Shi L. Risk factors and clinical analysis for invasive fungal infection in neonatal intensive care unit patients. Am J Perinatol; 2013，30(7):589-94. *(corresponding author)

34.  Ying Lv , Li-Li Tang , Jia-Kai Wei , Xue-Feng Xu , Weizhong Gu , Lin-Chen Fu , Li-Yan Zhang , *Li-Zhong Du.Decreased Kv1.5 expression in intrauterine growth retardation rats with exaggerated pulmonary hypertension. American Journal of Physiology - Lung Cellular and Molecular Physiology. 2013；305(11):L856-865 *(corresponding author)

35.  Liyan Zhang, Lili Tang, Jiakai Wei, Linjiang Lao, Weizhong Gu, Qiongyao Hu, Ying Lv,

Linchen Fu, and *Lizhong Du. Extrauterine growth restriction on pulmonary vascular endothelial dysfunction in adult male rats: the role of epigenetic mechanisms. Journal of Hypertension 2014, 32:2188–2198*(corresponding author)

36.  Xue-Feng Xu, Qiong-Yao Hu, Ling-Fang Liang, Lei Wu, Wei-Zhong Gu, Li-Li Tang, Lin-Chen Fu, and Li-Zhong Du*.Epigenetics of hyper-responsiveness to allergen challenge following intrauterine growth retardation rat. Respiratory Research 2014, 15:137,1-10*(corresponding author)

37.  Li-Li Tang, Li-Yan Zhang, Lin-Jiang Lao, Qiong-Yao Hu, Wei-Zhong Gu, Lin-Chen Fu, Li-Zhong Du*. Epigenetics of Notch1 regulation in pulmonary microvascular rarefaction following extrauterine growth restriction. Respiratory Research. 2015,16:66;1-10*(corresponding author)

38.  Hui‑Jia Lin, Li‑Zhong Du^*, Xiao‑Lu Ma, Li‑Ping Shi, Jia‑Hua Pan, et al. Mortality and Morbidity of Extremely Low Birth Weight Infants in the Mainland of China: A Multi‑center Study. Chinese Medical Journal, 2015;128(20):2743-2750*(corresponding author)

39.  Angelo A. Lamola*,Vinod K. Bhutani, Lizhong Du, Martin Castillo Cuadrado, Lihua Chen, Zheng Shen,Ronald J. Wong,David K. Stevenson. Neonatal bilirubin binding capacity discerns risk of neurological dysfunction. Pediatric Research

40.  Chen‑Hong Wang, Li‑Zhong Du, Xiao‑Lu Ma,et al. Analysis of In‑hospital Neonatal Death in the Tertiary Neonatal Intensive Care Unit in China: A Multicenter Retrospective Study. Chinese Medical Journal ;November 2016*(corresponding author)

41.   Xu YP, He Q, Shen Z, Shu XL, Wang CH, Zhu JJ, Shi LP, Du LZ

MiR-126a-5p is involved in the hypoxia-induced endothelial-to-mesenchymal transition of neonatal pulmonary hypertension. Hypertens Res. 2017 Jun;40(6):552-561*(corresponding author)

42.   Zhi-Qun Zhang，Ying Zhong，Xian-Mei Huang， and Li-Zhong Du. Airway administration of corticosteroids for prevention of bronchopulmonary dysplasia in premature infants: a meta-analysis with trial sequential analysis. BMC Pulmonary Medicine (2017) 17:207*(corresponding author)

43.   Yu Wang, Lingling Yan, Ziming Zhang, Eric Prado, Linchen Fu，Xuefeng Xu and Lizhong Du*. Epigenetic Regulation and its therateutic potential in pulmonary hypertension. Front Pharmacol 2018, 20 Mar 1-29. *(corresponding author)

 管敏鑫，“973”计划项目首席科学家，曾担任第四届亚洲线粒体研究与医学学会（ASMRM）主席（2011-2014），美洲华人遗传学会主席（2007-2008），多伦多大学（University of Toronto）和加州大学圣地亚哥分校（University of California at San Diego ）兼职教授（Adjunct Professor）。